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Taking Desvenlafaxine with other drugs that make you sleepy or slow your breathing can increase these effects. Ask your doctor before taking Desvenlafaxine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety or seizures.

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• any other antidepressant;
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• lithium;
• midazolam;
• imatinib;
• St. John's wort;
• tryptophan (sometimes called L-tryptophan);
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• pain medication--fentanyl or tramadol.

This list is not complete and many other drugs can interact with Desvenlafaxine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

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